一、基本信息
毛志强，教授，博士生导师，省级人才
研究领域：荧光探针与活体成像、重大疾病的分子诊疗
电子邮件：maozq@hubu.edu.cn
二、教育背景及工作经历
2024.10—至今 湖北大学 健康科学与工程学院，教授
2022.3—2023.3 韩国 高丽大学(Korea University) 化学系，访问学者
2019.7-2024.9 湖北大学 化学化工学院、健康科学与工程学院，副教授
2018.2—2019.6 湖北大学 化学化工学院，讲师
2017.7—2018.1 中南民族大学，研究助理
2012.9—2017.6 武汉大学，博士，分析化学
三、研究方向
主要研究方向包括近红外分子荧光探针的研制及活体成像分析，涉及脑疾病的分子影像、肿瘤联合治疗等领域，主持国家自然科学基金项目2项、湖北省自然科学基金项目1项，以第一作者/通讯作者在Nat. Commun. (1篇), Angew. Chem. Int. Ed. (2篇), Matter (1篇), Adv. Funct. Mater. (1篇）, Advanced Science (1篇）, Coordination Chemistry Reviews (4篇), Analytical Chemistry (5篇), Chemical Science (3篇), J. Hazard. Mater. (1篇)等国际学术刊物发表SCI论文40余篇，教学研究论文2篇，申请专利5项；长期应邀担任Advanced Materials, Chemical Science, Analytical Chemistry等期刊论文审稿人，担任Journal of Analysis and Testing等学术期刊青年编委。
四、科研项目
1. 国家自然科学基金面上项目，项目批准号：22174034，2022-01至2025-12，78万元，主持，在研。
2. 国家自然科学基金青年项目，项目批准号：21804033，2019-01至2021-12，31.1万元，主持，结题。
3. 湖北省自然科学基金面上项目，项目批准号：2021CFB305，2021-10至2023-09，8.0万元，主持，结题。
五、代表性论文
1. Miantai Ye, Xiaoyu Wang, Jingwen Zou, Wei Sun, Weijie Chi,* Zhiqiang Mao,* Zhihong Liu,* Breaking shackles of molecular weight and emission for NIR-II fluorophores by regulating Columb attraction interaction, Nature Communications, 2025, 16, 8007. (SCI一区，IF=15.7)
2. Jiankang Gong, Xiaoyu Wang, Jiao Wu, Changyu Yoon, Yujin Kim, Jingwen Zou, Zhiqiang Mao,* Jong Seung Kim,* Diaminonaphthalene Boronic Acid (DANBA): New Approach for Peroxynitrite Sensing Site. Angew. Chem. Int. Ed. 2024, 63, e202409295. (SCI一区，IF=16.1)
3. Pengzhang Wang, Le Yu, Jiankang Gong, Jianhua Xiong, Soyu Zi, Hua Xie, Fan Zhang, Zhiqiang Mao,* Zhihong Liu,* Jong Seung Kim.* An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO-) in the Alzheimer's Disease Brain. Angew. Chem. Int. Ed. 2022, 61, e202206894. (SCI一区，IF=16.823)
4. Jianhua Xiong, Pengzhan Wang, Subin Son, Zhong Cheng, Fan Zhang, Zhiqiang Mao,* Zhihong Liu,* Jong Seung Kim.* Engineering a theranostic platform for synergistic hypoxia-responsive photodynamic therapy and chemotherapy. Matter 2022, 5, 1502-1519. (SCI一区, IF=19.967)
5. Zhiqiang Mao, Hyeonji Rha, Jungryun Kim, Xinru You, Fan Zhang,* Wei Tao,* Jong Seung Kim.* THQ–Xanthene: An Emerging Strategy to Create Next-Generation NIR-I/II Fluorophores. Advanced Science, 2023, 10, 2301177. (SCI一区, IF=17.521)
6. Jianhua Xiong, Xiaoyu Wang, Jaewon Kim, Jiankang Gong, Zhiqiang Mao,* Jong Seung Kim,* Zhihong Liu.* Tumor-Activated Prodrug with Synergistic Anti-Stemness Chemical and Photodynamic Therapies. Advanced Functional Materials, 2024, 34，2312590. (SCI一区，IF=19.0)
7. Xiaoyu Wang, Weijie Chi,* Jiao Wu, Jingwen Zou, Jiyoung Yoo, Seokjin Hong, Fan Zhang, Zhiqiang Mao,* Jong Seung Kim,* A NIR-II emissive sonosensitized biotuner for pyroptosis-enhanced sonodynamic therapy of hypoxic tumors. Biomaterials, 2025, 315, 122969. (SCI一区，IF=12.9)
8. Jianhua Xiong, Weijie Chi, Miantai Ye, Li Zhang, Xiaoyu Wang, Zhiqiang Mao,* and Zhihong Liu.* Activatable Phototherapeutic Prodrug Conquering Hypoxia Limitation to Enhance Chemical Drug Delivery Efficiency. ACS Materials Letters 2024, 6, 2548−2558. (SCI一区， IF=11.4)
9. Zhiqiang Mao, Jianhua Xiong, Pengzhan Wang, Jusung An, Fan Zhang, Zhihong Liu,* Jong Seung Kim.* Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes. Coordination Chemistry Reviews 2022, 454, 214356. (SCI一区，IF=24.833)
10. Zhiqiang Mao, Ji Hyeon Kim, Jieun Lee, Hao Xiong, Fan Zhang,* Jong Seung Kim.* Engineering of BODIPY-based theranostics for cancer therapy, Coordination Chemistry Reviews 2023, 476, 214908. (SCI一区，IF=24.833)
11. Xiaoyu Wang, Jiankang Gong, Jiaxuan Wang, Fan Zhang, Zhiqiang Mao*, Zhihong Liu*. Engineering molecular theranostic probes for antibaterial therapy. Trends in Analytical Chemistry, 2023, 167, 117232. (SCI一区， IF=13.1)
12. Maintai Ye, Yunhui Xiang, Jiankang Gong, Xiaoyu Wang, Zhiqiang Mao,* Zhihong Liu.* Monitoring Hg2+ and MeHg+ Poisoning in Living Body with An Activatable Near-infrared II Fluorescence Probe, Journal of Hazardous Materials, 2023, 445, 130612. (SCI一区，IF=14.224)
13. Songjiao Li, Peipei Wang, Miantai Ye, Ke Yang, Dan Cheng, Zhiqiang Mao*, Longwei He*, and Zhihong Liu. Cysteine-Activatable Near-Infrared Fluorescent Probe for Dual-Channel Tracking Lipid Droplets and Mitochondria in Epilepsy. Analytical Chemistry, 2023, 95, 5133–5141. (SCI一区，IF=8.008)
14. Pengzhan Wang, Xianhua Cheng, Jianhua Xiong, Zhiqiang Mao,* Zhihong Liu.* Revealing Formaldehyde Fluxes in Alzheimer's Disease Brain by an Activity-Based Fluorescence Probe. Chinese Journal of Chemistry 2022, 40, 1457-1463. (SCI二区， IF=5.560)
15. Zhao Wang, Weiwei Wang, Pengzhan Wang, Zhiqiang Mao,* Zhihong Liu.* Highly Sensitive Near-Infrared Imaging of Peroxynitrite Fluxes in Inflammation Progress. Analytical Chemistry 2021, 93, 3035-3041. (SCI一区，IF=6.986)
16. Weiwei Wang, Jianhua Xiong, Xinjian Song, Zhao Wang, Fan Zhang, Zhiqiang Mao.* Activatable Two-Photon Near-Infrared Fluorescent Probe Tailored toward Peroxynitrite In Vivo Imaging in Tumors. Analytical Chemistry 2020, 92, 13305-13312. (SCI一区，IF=6.785)
17. Jianhua Xiong, Weiwei Wang, Caixia Wang, Cheng Zhong, Renqiang Ruan, Zhiqiang Mao*, Zhihong Liu.* Visualizing Peroxynitrite in Microvessels of the Brain with Stroke Using an Engineered Highly Specific Fluorescent Probe. ACS Sensors 2020, 5, 3237-3245. (SCI一区，IF=7.333)
18. Yan Lou, Caixia Wang, Siyu Chi, Songjiao Li, Zhiqiang Mao* and Zhihong Liu.* Construction of a two-photon fluorescent probe for ratiometric imaging of hypochlorous acid in alcohol-induced liver injury. Chemical Communications 2019, 55, 12912-12915. (SCI一区，IF=6.164)
19. Zhiqiang Mao, Miantai Ye, Wei Hu, Xiaoxue Ye, Yanying Wang, Huijuan Zhang, Chunya Li* and Zhihong Liu.* Design of a ratiometric two-photon probe for imaging of hypochlorous acid (HClO) in wounded tissues. Chemical Science 2018, 9, 6035-6040. (SCI一区，IF=9.556)
20. Zhiqiang Mao, Hong Jiang, Xinjian Song, Wei Hu and Zhihong Liu.* Development of a Silicon-Rhodamine Based Near-Infrared Emissive Two-Photon Fluorescent Probe for Nitric Oxide. Analytical Chemistry 2017, 89, 9620-9624. (SCI一区，IF=6.042)
21. Zhiqiang Mao, Hong Jiang, Zhen Li, Cheng Zhong, Wei Zhang and Zhihong Liu.* An N-nitrosation reactivity-based two-photon fluorescent probe for the specific in situ detection of nitric oxide. Chemical Science 2017, 8, 4533-4538. (SCI一区，IF=9.063)
22. Zhiqiang Mao, Wenqi Feng, Zhen Li, Lingyu Zeng, Weijie Lv and Zhihong Liu*. NIR in, far-red out: developing a two-photon fluorescent probe for tracking nitric oxide in deep tissue. Chemical Science 2016, 7, 5230-5235. (SCI一区，IF=8.668)
23. Zhiqiang Mao, Liang Hu, ChengZhong, Heng Zhang, Bi-Feng Liu* and Zhihong Liu*. A dual-mechanism strategy to design a wide-range pH probe with multicolor fluorescence. Sensor. Actuat. B-Chem. 2015, 219, 179-184. (SCI一区，IF=4.758)
24. Zhiqiang Mao, Liang Hu, Xiaohu Dong, Cheng Zhong, Bi-Feng Liu and Zhihong Liu*. Highly Sensitive Quinoline-Based Two-Photon Fluorescent Probe for Monitoring Intracellular Free Zinc Ions. Analytical Chemistry 2014, 86, 6548-6554. (SCI一区，IF=5.825)
