一、基本信息
李贞，教授，博士生导师。2016年获武汉大学分析化学专业理学博士学位，2017年入选“中国博士后创新人才支持计划”，2019年入选湖北省“楚天学者计划-楚天学子”，2022年获批湖北省自然科学基金杰出青年项目支持，主持国家自然科学基金面上项目2项，青年项目1项。研究领域为稀土荧光纳米探针及生物成像，主要从事稀土荧光纳米材料光物理性能调控、稀土纳米探针构建策略研发及脑科学应用研究等相关工作。近年来在JACS,ACS Nano, Adv. Sci.Adv. Funct. Mater., Anal. Chem.等期刊发表SCI论文50余篇。
研究领域：分子光谱
电子邮件：zhenli@hubu.edu.cn
二、教育背景及工作经历
教育背景
(1) 2011-09至2016-12,武汉大学,分析化学,博士
(2) 2007-09至2011-06,武汉大学,应用化学,学士
工作经历
(1) 2024-10至今,湖北大学,健康科学与工程学院,教授
(2) 2022-11至2024-09,湖北大学,健康科学与工程学院,副教授
(3) 2019-07至2022-10,湖北大学,化学化工学院,副教授
(4) 2019-03至2019-06,湖北大学,化学化工学院,讲师
(5) 2017-03至2019-02,武汉大学
三、研究方向
聚焦构建面向脑部化学测量的稀土荧光纳米探针，针对提高材料发光效率及开发第二近红外区（NIR-II）稀土荧光纳米探针激活策略等关键科学问题开展了系统研究。设计天线敏化稀土纳米颗粒（LnNPs）新材料，提出NIR-II探针激活新策略，发展NIR-II稀土荧光纳米探针的比率信号输出新模式，实现了复杂脑环境下高灵敏、高分辨率、高可靠性的可视化分析检测。
四、科研项目
1.近红外二区超声发光探针构建及活体成像应用，国家自然科学基金面上项目，2026.01－2029.12，主持。
2.NIR-II荧光成像介导的脑肿瘤精确诊断与辅助治疗，湖北省自然科学基金杰出青年项目，2022.06-2025.06，主持。
3.基于稀土纳米颗粒的NIR-IIb光动力治疗及疗效监测一体化平台，国家自然科学基金面上项目2022.01－2025.12，主持。
4.基于上转换荧光的可逆氧化还原探针的设计构建及应用，国家自然科学基金青年科学基金（C类），2019.01-2021.12，主持。
5.上转换纳米探针的设计构建及生物应用，2017.03-2019.02，中国博士后科学基金会，2017年度博士后创新人才支持计划，主持。
6.基于上转换荧光的线粒体靶向探针的设计构建及应用，中国博士后科学基金会，第62批中国博士后科学基金面上资助二等资助，2017.11-2018.10，主持。
五、代表性论文
1.Yujiao Guo, Rui Hu, Kaijie Ma, Wei-Hua Huang, Tao Liang*, Zhen Li*.Precise Tumor Delineation via Dual Fluorescence Lifetime Imaging.Anal. Chem.2025, 97,25692-25700.
2.Chenchen Li, Rui Huang, Kaijie Ma, Juan Ge, Tao Liang*, Zhen Li*.Specific Lung-Targeting Shortwave Infrared LuminescenceNanoprobe: Precisely Delineating Sepsis-Induced Acute Lung Injury.Anal. Chem.2025, 97,19294-19305.
3.Chenchen Li, Juan Ge, Dan Song, Tao Liang*, Zhen Li*.Activatable Near-Infrared IIb Rare-Earth Nanoprobe for EarlyMonitoring Chemotherapy-Induced Liver Injury.Adv.Funct.Mater. 2025, 35,2502077.
4.Jiaxin Fu, Mengting Zhu, Li Zhang, Chenchen Li, Tao Liang, Zhen Li*, Zhihong Liu*.Visualization of Oxidative Stress in the Early Stage of Alzheimer’sDisease with a NIR-IIb Probe.Anal. Chem.2025, 97,5038-5048.
5.Mengting Zhu, Tao Liang, Yupei Zhao, Zhen Li*.miR-21-Trigged Precise Photodynamic Therapy Through a“Locking-Unlocking-Boosting” ROS Production Strategy.Adv.Funct.Mater. 2025, 35,2418016.
6.Yong Wan, Zhi Guo, Zhengjun Wu, Tao Liang*, Zhen Li*.Visualization of diabetes progression by an activatable NIR-IIb luminescence probe.Anal. Chem.2024, 96, 14843-14852.
7.Zhuo Tu, Yong Wan, Juan Ge, Chenchen Li, Tao Liang*, Zhen Li*.NIR-IIb-triggered photodynamic therapy combined with chemotherapy platform based on rare-earth-doped nanoparticles.Rare Metals2024, 43, 3220-3231.
8.Chenchen Li, Wenqiang Bi, Tao Liang, Zhen Li*, Zhihong Liu*.Revealing the role of nitroxyl during hepaticischemia-reperfusion injury with a NIR-IIluminescent nanoprobe,Chem. Sci.2023, 14, 7743.
9.Juan Ge, Miaomiao Zuo, Qirong, Wang, Zhen Li. Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma.J. Nanobiotechnol.2023, 21, 48.
10.Qian Duan, Yifan He, Wenqiang Bi, Tao Liang*, Zhihong Liu, and Zhen Li*.In Vivo Monitoring of Hydrogen Polysulfide via a NIR-ExcitableReversible Fluorescent Probe Based on Upconversion LuminescenceResonance Energy Transfer,Anal. Chem.2022, 94, 8792-8801.
11.Tao Liang, Zhi Guo, Yifan He, Yanying Wang, Chunya Li*, Zhen Li*, Zhihong Liu*.Cyanine-Doped Lanthanide Metal-Organic Frameworks for Near-Infrared II Bioimaging,Adv. Sci.2022, 9, 2104561.
12.Dan Song, Mengting Zhu, Chenchen Li, Yan Zhou, Yudan Xie, Zhen Li*, Zhihong Liu. Boosting and Activating NIR-IIb Luminescence of Ag2Te Quantum Dots with a Molecular Trigger.Anal. Chem.2021, 93, 16932-16939.
13.Zhen Li#, Caixia Wang#, Meng Zhang, Songjiao Li, Zhiqiang Mao, Zhihong Liu*. Activatable Luminescent Probes for Imaging Brain Diseases,Nano Today2021, 39, 101239.
14.Meng Zhang, Zijun Wang, Caixia Wang, Yuting Wu, Zhen Li*, Zhihong Liu*. Visualizing Oxidative Stress Level for Timely Assessment of Ischemic Stroke via a Ratiometric NIR-II Luminescent Nanoprobe,ACSNano2021, 15, 11940-11952.
15.Qirong Wang#, Tao Liang#, Junjie Wu, Zhen Li*, Zhihong Liu. Dye-Sensitized Rare Earth-Doped Nanoparticles with Boosted NIR-IIb Emission for Dynamic Imaging of Vascular Network-Related Disorders,ACSAppl.Mater.Interfaces2021, 13, 29303-29312.
16.Dan Song, Mengting Zhu, Siyu Chi, Lan Xia, Zhen Li*, Zhihong Liu*. Sensitizing the Luminescence of Lanthanide-Doped Nanoparticles over 1500 nm for High-Contrast and Deep Imaging of Brain Injury,Anal.Chem. 2021, 2021, 93, 7949-7957
17.Miaomiao Zuo, Qian Duan, Chenchen Li, Juan Ge, Qirong Wang, Zhen Li*, Zhihong Liu. A Versatile Strategy for Constructing Ratiometric Upconversion Luminescent Probe with Sensitized Emission of Energy Acceptor,Anal.Chem. 2021, 93, 5635-5643.
18.Tao Liang, Qirong Wang, Zhen Li*, Peipei Wang, Junjie Wu, Miaomiao Zuo, Zhihong Liu*. Removing the Obstacle of Dye-Sensitized Upconversion Luminescence in Aqueous Phase to Achieve High-Contrast Deep Imaging in Vivo,Adv.Funct.Mater. 2020, 30, 1910765.
19.Meng Zhang, Miaomiao Zuo, Caixia Wang, Zhen Li*, Qingyuan Cheng, Ju Huang, Zijun Wang, Zhihong Liu*. Monitoring Neuroinflammation with an HOCl-Activatable and Blood-Brain Barrier Permeable Upconversion Nanoprobe,Anal.Chem. 2020, 92, 5569-5576.
20.Zhen Li, Junjie Wu, Qirong Wang, Tao Liang, Juan Ge, Peipei Wang, Zhihong Liu*. A Universal Strategy to Construct Lanthanide-Doped Nanoparticles-Based Activable NIR-II Luminescence Probe for Bioimaging,iScience2020, 23, 100962.
21.Songjiao Li, Dan Song, Weijing Huang, Zhen Li*, Zhihong Liu. In Situ Imaging of Cysteine in the Brains of Mice with Epilepsy by a Near-Infrared Emissive Fluorescent Probe,Anal.Chem. 2020, 92, 2802-2808.
22.Zhen Li, Tao Liang, Qirong Wang, Zhihong Liu*. Strategies for Constructing Upconversion Luminescence Nanoprobes to Improve Signal Contrast.Small2020, 16, 1905084.
23.Dan Song, Siyu Chi, Xin Li, Caixia Wang, Zhen Li*, Zhihong Liu*. Upconversion System with Quantum Dots as Sensitizer: Improved Photoluminescence and PDT Efficiency,ACSAppl.Mater.Interfaces2019, 11, 41100-41108.
24.Xiaoxue Ye#, Yunhui Xiang#, Qirong Wang, Zhen Li*, Zhihong Liu*. A Red Emissive Two-Photon Fluorescence Probe Based on Carbon Dots for Intracellular pH Detection,Small2019, 15, 1901673
25.Tao Liang, Zhen Li*, Peipei Wang, Fangzhou Zhao, Jizhou Liu, Zhihong Liu*. Breaking Through the Signal-to-Background Limit of Upconversion Nanoprobes Using a Target-Modulated Sensitizing Switch.J. Am. Chem. Soc.2018, 140, 14696-14703.
26.Yuping Han, Lin Shen, Zhen Li*, Zhihong Liu*, A Strategy to Facilitate the Assembly of DNA and Upconversion Nanoparticles for Biosensor Construction,Anal.Methods2018, 10, 3933-3938.
27.Zhen Li, Tao Liang, Songwei Lv, Qinggeng Zhuang, Zhihong Liu*.J. Am. Chem. Soc.2015, 137, 11179-11185.
28.Zhen Li, Songwei Lv, Yali Wang, Shiyu Chen, Zhihong Liu*.J. Am. Chem. Soc.2015, 137, 3421-3427.
29.Zhen Li, Mengyuan He, Dangdang Xu, Zhihong Liu*.J. Photochem. Photobio. C: Photochemistry Reviews2014, 18, 1-17.
