一、基本信息
李贞，教授，博士生导师，生物医学工程系主任。2016年获武汉大学分析化学专业理学博士学位，2017年入选“中国博士后创新人才支持计划”，2019年入选湖北省“楚天学者计划-楚天学子”，2022年获批湖北省自然科学基金杰出青年项目支持，承担国家自然科学基金面上项目1项，青年项目1项。研究领域为稀土荧光纳米探针及生物成像，主要从事稀土荧光纳米材料光物理性能调控、稀土纳米探针构建策略研发及脑科学应用研究等相关工作。近五年在JACS, ACS Nano, Adv. Sci. Adv. Funct. Mater., Anal. Chem.等期刊发表SCI论文30余篇。
研究领域：分子光谱
电子邮件：zhenli@hubu.edu.cn
二、教育背景及工作经历
教育背景
(1) 2011-09 至 2016-12, 武汉大学, 分析化学, 博士
(2) 2007-09 至 2011-06, 武汉大学, 应用化学, 学士
工作经历
(1) 2024-10 至 今, 湖北大学, 健康科学与工程学院, 教授
(2) 2022-11 至 2024-09, 湖北大学, 健康科学与工程学院, 副教授
(3) 2019-07 至 2022-10, 湖北大学, 化学化工学院, 副教授
(4) 2019-03 至 2019-06, 湖北大学, 化学化工学院, 讲师
(5) 2017-03 至 2019-02, 武汉大学
三、研究方向
聚焦构建面向脑部化学测量的稀土荧光纳米探针，针对提高材料发光效率及开发第二近红外区（NIR-II）稀土荧光纳米探针激活策略等关键科学问题开展了系统研究。设计天线敏化稀土纳米颗粒（LnNPs）新材料，提出NIR-II探针激活新策略，发展NIR-II稀土荧光纳米探针的比率信号输出新模式，实现了复杂脑环境下高灵敏、高分辨率、高可靠性的可视化分析检测。
四、科研项目
1. NIR-II 荧光成像介导的脑肿瘤精确诊断与辅助治疗，湖北省自然科学基金杰出青年项目，2022.06-2025.06，主持。
2. 基于稀土纳米颗粒的NIR-IIb光动力治疗及疗效监测一体化平台，国家自然科学基金面上项目，2022.01－2025.12，主持。
3. 基于上转换荧光的可逆氧化还原探针的设计构建及应用，国家自然科学基金青年科学基金，2019.01-2021.12，主持。
4. 上转换纳米探针的设计构建及生物应用，2017.03-2019.02，中国博士后科学基金会，2017年度博士后创新人才支持计划，主持。
5. 基于上转换荧光的线粒体靶向探针的设计构建及应用，中国博士后科学基金会，第62批中国博士后科学基金面上资助二等资助，2017.11-2018.10，主持。
五、代表性论文
1. Yong Wan, Zhi Guo, Zhengjun Wu, Tao Liang*, Zhen Li*. Visualization of diabetes progression by an activatable NIR-IIb luminescence probe. Anal. Chem. 2024, 96, 14843-14852.
2. Zhuo Tu, Yong Wan, Juan Ge, Chenchen Li, Tao Liang*, Zhen Li*. NIR-IIb-triggered photodynamic therapy combined with chemotherapy platform based on rare-earth-doped nanoparticles. Rare Metals 2024, 43, 3220-3231.
3. Chenchen Li, Wenqiang Bi, Tao Liang, Zhen Li*, Zhihong Liu*. Revealing the role of nitroxyl during hepatic ischemia-reperfusion injury with a NIR-II luminescent nanoprobe, Chem. Sci. 2023, 14, 7743.
4. Juan Ge, Miaomiao Zuo, Qirong, Wang, Zhen Li. Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma. J. Nanobiotechnol. 2023, 21, 48.
5. Qian Duan, Yifan He, Wenqiang Bi, Tao Liang,* Zhihong Liu, and Zhen Li*. In Vivo Monitoring of Hydrogen Polysulfide via a NIR-Excitable Reversible Fluorescent Probe Based on Upconversion Luminescence Resonance Energy Transfer, Anal. Chem. 2022, 94, 8792-8801.
6. Tao Liang, Zhi Guo, Yifan He, Yanying Wang, Chunya Li*, Zhen Li*, Zhihong Liu*. Cyanine-Doped Lanthanide Metal-Organic Frameworks for Near-Infrared II Bioimaging, Adv. Sci. 2022, 9, 2104561.
7. Dan Song, Mengting Zhu, Chenchen Li, Yan Zhou, Yudan Xie, Zhen Li*, Zhihong Liu. Boosting and Activating NIR-IIb Luminescence of Ag2Te Quantum Dots with a Molecular Trigger. Anal. Chem. 2021, 93, 16932-16939.
8. Zhen Li#, Caixia Wang#, Meng Zhang, Songjiao Li, Zhiqiang Mao, Zhihong Liu*. Activatable Luminescent Probes for Imaging Brain Diseases, Nano Today 2021, 39, 101239.
9. Meng Zhang, Zijun Wang, Caixia Wang, Yuting Wu, Zhen Li*, Zhihong Liu*. Visualizing Oxidative Stress Level for Timely Assessment of Ischemic Stroke via a Ratiometric NIR-II Luminescent Nanoprobe, ACS Nano 2021, 15, 11940-11952.
10. Qirong Wang#, Tao Liang#, Junjie Wu, Zhen Li*, Zhihong Liu. Dye-Sensitized Rare Earth-Doped Nanoparticles with Boosted NIR-IIb Emission for Dynamic Imaging of Vascular Network-Related Disorders, ACS Appl. Mater. Interfaces 2021, 13, 29303-29312.
11. Dan Song, Mengting Zhu, Siyu Chi, Lan Xia, Zhen Li*, Zhihong Liu*. Sensitizing the Luminescence of Lanthanide-Doped Nanoparticles over 1500 nm for High-Contrast and Deep Imaging of Brain Injury, Anal. Chem. 2021, 2021, 93, 7949-7957
12. Miaomiao Zuo, Qian Duan, Chenchen Li, Juan Ge, Qirong Wang, Zhen Li*, Zhihong Liu. A Versatile Strategy for Constructing Ratiometric Upconversion Luminescent Probe with Sensitized Emission of Energy Acceptor, Anal. Chem. 2021, 93, 5635-5643.
13. Tao Liang, Qirong Wang, Zhen Li*, Peipei Wang, Junjie Wu, Miaomiao Zuo, Zhihong Liu*. Removing the Obstacle of Dye-Sensitized Upconversion Luminescence in Aqueous Phase to Achieve High-Contrast Deep Imaging in Vivo, Adv. Funct. Mater. 2020, 30, 1910765.
14. Meng Zhang, Miaomiao Zuo, Caixia Wang, Zhen Li*, Qingyuan Cheng, Ju Huang, Zijun Wang, Zhihong Liu*. Monitoring Neuroinflammation with an HOCl-Activatable and Blood-Brain Barrier Permeable Upconversion Nanoprobe, Anal. Chem. 2020, 92, 5569-5576.
15. Zhen Li, Junjie Wu, Qirong Wang, Tao Liang, Juan Ge, Peipei Wang, Zhihong Liu*. A Universal Strategy to Construct Lanthanide-Doped Nanoparticles-Based Activable NIR-II Luminescence Probe for Bioimaging, iScience 2020, 23, 100962.
16. Songjiao Li, Dan Song, Weijing Huang, Zhen Li*, Zhihong Liu. In Situ Imaging of Cysteine in the Brains of Mice with Epilepsy by a Near-Infrared Emissive Fluorescent Probe, Anal. Chem. 2020, 92, 2802-2808.
17. Zhen Li, Tao Liang, Qirong Wang, Zhihong Liu*. Strategies for Constructing Upconversion Luminescence Nanoprobes to Improve Signal Contrast. Small 2020, 16, 1905084.
18. Dan Song, Siyu Chi, Xin Li, Caixia Wang, Zhen Li*, Zhihong Liu*. Upconversion System with Quantum Dots as Sensitizer: Improved Photoluminescence and PDT Efficiency, ACS Appl. Mater. Interfaces 2019, 11, 41100-41108.
19. Xiaoxue Ye#, Yunhui Xiang#, Qirong Wang, Zhen Li*, Zhihong Liu*. A Red Emissive Two-Photon Fluorescence Probe Based on Carbon Dots for Intracellular pH Detection, Small 2019, 15, 1901673
20. Tao Liang, Zhen Li*, Peipei Wang, Fangzhou Zhao, Jizhou Liu, Zhihong Liu*. Breaking Through the Signal-to-Background Limit of Upconversion Nanoprobes Using a Target-Modulated Sensitizing Switch. J. Am. Chem. Soc. 2018, 140, 14696-14703.
21. Yuping Han, Lin Shen, Zhen Li*, Zhihong Liu*, A Strategy to Facilitate the Assembly of DNA and Upconversion Nanoparticles for Biosensor Construction, Anal. Methods 2018, 10, 3933-3938.
22. Zhen Li, Tao Liang, Songwei Lv, Qinggeng Zhuang, Zhihong Liu*. J. Am. Chem. Soc. 2015, 137, 11179-11185.
23. Zhen Li, Songwei Lv, Yali Wang, Shiyu Chen, Zhihong Liu*. J. Am. Chem. Soc. 2015, 137, 3421-3427.
24. Zhen Li, Mengyuan He, Dangdang Xu, Zhihong Liu*. J. Photochem. Photobio. C: Photochemistry Reviews 2014, 18, 1-17.
